Thesis
Cavitation-enhanced delivery of therapeutics to solid tumors
- Abstract:
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Poor drug penetration through tumor tissue has emerged as a fundamental obstacle to cancer therapy. The solid tumor microenvironment presents several physiological abnormalities which reduce the uptake of intravenously administered therapeutics, including leaky, irregularly spaced blood vessels, and a pressure gradient which resists transport of therapeutics from the bloodstream into the tumor. Because of these factors, a systemically administered anti-cancer agent is unlikely to reach 100...
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Funding
+ Engineering and Physical Sciences Research Council
More from this funder
Funding agency for:
Rifai, B
Grant:
EP/F011547/1
EP/F033710/1
Bibliographic Details
- Publication date:
- 2011
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:374b2ee1-0711-4994-8434-bf90358d9e47
- Local pid:
- ora:12128
- Deposit date:
- 2015-08-13
Terms of use
- Copyright holder:
- Rifai, B
- Copyright date:
- 2011
- Notes:
- This thesis is not currently available in ORA
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