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Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder: a cross-national cohort study of 4.5 million individuals and their siblings

Abstract:

Background: A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder (ASD). Subsequent replication attempts have lacked sufficient power to confidently exclude the possibility of a small effect and the causal nature of this association remains unknown.

Objective: To investigate the extent to which exposure to labor epidural analgesia is associated with offspring ASD and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.ajog.2022.08.016

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Name:
Wellcome Trust
Grant:
202836/Z/16/Z
Publisher:
Elsevier
Journal:
American Journal of Obstetrics and Gynecology More from this journal
Volume:
228
Issue:
2
Pages:
233.E1-233.E12
Publication date:
2022-08-13
Acceptance date:
2022-08-11
DOI:
ISSN:
0002-9378
Language:
English
Keywords:
Pubs id:
1273692
Local pid:
pubs:1273692
Deposit date:
2022-08-12

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