The role of matrix metalloproteinases in rheumatoid tendon disease.

Journal article

In rheumatoid arthritis (RA) invasive tenosynovitis is associated with an increase in tendon rupture, although little is known about the mechanisms involved. We obtained specimens of noninvasive encapsulating tenosynovium, invasive tenosynovium, and wrist joint synovium from 28 rheumatoid patients. In vitro production of the matrix metalloproteinase (MMP) enzymes, MMP-8 and -9, and total collagenase activity were measured. Invasive tenosynovium produced highest levels of the collagenase MMP-8...

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Authors: Jain, A; Brennan, F; Troeberg, L; Nanchahal, J

• Publication status: Published
• Journal: Journal of hand surgery
• Volume: 27
• Issue: 6
• Pages: 1059-1064
• Publication date: 2002-11-01
• DOI: 10.1053/jhsu.2002.36516
• EISSN: 1531-6564
• ISSN: 0363-5023
• Language: English
• Keywords: Data Interpretation, Statistical; Rupture; Synovial Membrane; Matrix Metalloproteinase 9; Collagen Type I; Aged; Wrist Joint; Humans; Tendons; Aged, 80 and over; Adult; Arthritis, Rheumatoid; Cells, Cultured; Matrix Metalloproteinase 8; Enzyme-Linked Immunosorbent Assay; Female; Male; Middle Aged