The recombinant origin of emerging human norovirus GII.4/2008: Intra-genotypic exchange of the capsid P2 domain

Journal article

GII.4 noroviruses are a major cause of acute gastroenteritis in humans. A new variant of GII.4, the 2008 variant, has recently increased its prevalence on a global scale. A previous study of this variant in Japan suggested that it might be of recombinant origin, with a breakpoint at the ORF1-ORF2 junction. Here, examination of the evolutionary origin of the 2008 variant based on a larger sample of worldwide GII.4 norovirus sequences revealed a more complex pattern of recombination between the...

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Authors: Lam, T; Zhu, H; Smith, D; Guan, Y; Holmes, E

• Journal: Journal of General Virology
• Volume: 93
• Issue: 4
• Pages: 817-822
• Publication date: 2012-04-01
• DOI: 10.1099/vir.0.039057-0
• EISSN: 1465-2099
• ISSN: 0022-1317
• Language: English