Direct studies of ligand-receptor interactions and ion channel blocking (Review).

Journal article

Small molecules can activate membrane bound receptors to elicit cellular responses and approximately 80% of all such responses are mediated through membranes. Solid state nuclear magnetic resonance (NMR) methods have been developed for the resolution of specifically labelled ligands, designed to report back structural, dynamic and electronic details of the ligand whilst at its site of action. In particular, ion channel blockers, drugs, inhibitors, prosthetic groups and solutes have been studi...

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Authors: Watts, A

• Publication status: Published
• Journal: Molecular membrane biology
• Volume: 19
• Issue: 4
• Pages: 267-275
• Publication date: 2002-01-01
• DOI: 10.1080/0968768021000035113
• EISSN: 1464-5203
• ISSN: 0968-7688
• Language: English
• Keywords: Humans; Ion Channels; Ligands; Ion Channel Gating; Animals; Pyridines; Ouabain; Sodium-Potassium-Exchanging ATPase; Ion Transport