Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.

Journal article

Malaria in pregnancy is associated with maternal and fetal morbidity and mortality. In 2006, WHO recommended use of artemisinin-based combination treatments during the second or third trimesters, but data on efficacy and safety in Africa were scarce. We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda.

Authors: Piola, P; Nabasumba, C; Turyakira, E; Dhorda, M; Lindegardh, N

• Journal: Lancet Infect Dis
• Volume: 10
• Issue: 11
• Pages: 762-769
• Publication date: 2010-11-01
• DOI: 10.1016/S1473-3099(10)70202-4
• EISSN: 1474-4457
• ISSN: 1473-3099
• Language: English
• Keywords: Fluorenes; Ethanolamines; Adolescent; Pregnancy; Humans; Adult; Plasmodium falciparum; Artemisinins; Drug Combinations; Animals; Female; Treatment Outcome; Malaria, Falciparum; Young Adult; Polymerase Chain Reaction; Uganda; Quinine; Pregnancy Complications, Infectious; Antimalarials