Conference item
A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study
- Abstract:
-
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are characterized by an extreme variability, which cannot be reproduced by a single in silico model. Here we present a population of hiPSC-CM models, calibrated using six different experimental datasets. By sampling the maximum conductances of 11 ionic currents, 10000 parameter sets were obtained. The experimental data-based calibration selected 1355 in silico models to be included in the final population. Such population ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- IEEE Publisher's website
- Host title:
- 2016 Computing in Cardiology Conference (CinC)
- Journal:
- 2016 Computing in Cardiology Conference (CinC) Journal website
- Volume:
- 43
- Pages:
- 1189-1192
- Publication date:
- 2017-03-02
- Acceptance date:
- 2016-06-02
- DOI:
- EISSN:
-
2325-887X
- ISSN:
-
2325-8861
- ISBN:
- 9781509008964
Item Description
- Pubs id:
-
pubs:688789
- UUID:
-
uuid:3739df2d-6251-466a-a81c-943109e6309f
- Local pid:
- pubs:688789
- Source identifiers:
-
688789
- Deposit date:
- 2017-09-07
Terms of use
- Copyright holder:
- Paci et al
- Copyright date:
- 2017
- Notes:
-
Copyright © 2016 by the Authors, this article is licensed by its authors under the Creative Commons Attribution License
2.5 (CCAL).
- Licence:
- CC Attribution (CC BY)
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