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Optimization of virulence functions through glucosylation of Shigella LPS.

Abstract:

Shigella, the leading cause of bacillary dysentery, uses a type III secretion system (TTSS) to inject proteins into human cells, leading to bacterial invasion and a vigorous inflammatory response. The bacterium is protected against the response by the O antigen of lipopolysaccharide (LPS) on its surface. We show that bacteriophage-encoded glucosylation of Shigella O antigen, the basis of different serotypes, shortens the LPS molecule by around half. This enhances TTSS function without comprom...

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Publisher copy:
10.1126/science.1108472

Authors


Sansonetti, P More by this author
Mounier, J More by this author
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Journal:
Science (New York, N.Y.)
Volume:
307
Issue:
5713
Pages:
1313-1317
Publication date:
2005-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:373903af-d0aa-4fec-9fe0-2156d7f03e68
Source identifiers:
249500
Local pid:
pubs:249500

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