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Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosis.

Abstract:

BACKGROUND: Two antibiotic regimens are used commonly in Thailand for the initial treatment of severe melioidosis: ceftazidime in combination with trimethoprim-sulfamethoxazole (TMP-SMX) and ceftazidime monotherapy. It is not known whether TMP-SMX provides an additional benefit. METHODS: Two prospective, randomized trials that compared these regimens for patients presenting with acute severe melioidosis were started independently at tertiary care hospitals in Ubon Ratchathani and Khon Kaen (...

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Publication status:
Published

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Publisher copy:
10.1086/444456

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
41
Issue:
8
Pages:
1105-1113
Publication date:
2005-10-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:3737dd3b-8ca4-4e3c-8ad8-d9537b4305c3
Source identifiers:
17810
Local pid:
pubs:17810

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