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Association of leucine-rich glioma inactivated protein 1, contactin-associated protein 2, and contactin 2 antibodies with clinical features and patient-reported pain in acquired neuromyotonia

Abstract:

Importance Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)–complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement.

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1001/jamaneurol.2018.2681

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Pettingill, P More by this author
Pettingill, R More by this author
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British Medical Association Foundation More from this funder
Japan Society for the Promotion of Science More from this funder
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Publisher:
American Medical Association Publisher's website
Journal:
JAMA Neurology Journal website
Volume:
75
Issue:
12
Pages:
1519-1527
Publication date:
2018-09-17
Acceptance date:
2018-07-08
DOI:
EISSN:
2168-6157
ISSN:
2168-6149
Pubs id:
pubs:923562
URN:
uri:37173945-9697-4791-9ada-34134b14bfad
UUID:
uuid:37173945-9697-4791-9ada-34134b14bfad
Local pid:
pubs:923562
Language:
English

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