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The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

Abstract:

ATRX syndrome is characterized by X-linked mental retardation associated with alpha-thalassemia. The gene mutated in this disease, ATRX, encodes a plant homeodomain-like finger and a SWI2/SNF2-like ATPase motif, both of which are often found in chromatin-remodeling enzymes, but ATRX has not been characterized biochemically. By immunoprecipitation from HeLa extract, we found that ATRX is in a complex with transcription cofactor Daxx. The following evidence supports that ATRX and Daxx are compo...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1937626100

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
McDowell, TL More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
100
Issue:
19
Pages:
10635-10640
Publication date:
2003-09-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:370fc0b0-b651-4fdb-8f97-5a0354347a5b
Source identifiers:
253421
Local pid:
pubs:253421

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