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Full-length characterization of hepatitis C virus subtype 3a reveals novel hypervariable regions under positive selection during acute infection

Abstract:

Hepatitis C virus subtype 3a is a highly prevalent and globally distributed strain that is often associated with infection via injection drug use. This subtype exhibits particular phenotypic characteristics. In spite of this, detailed genetic analysis of this subtype has rarely been performed. We performed full-length viral sequence analysis in 18 patients with chronic HCV subtype 3a infection and assessed genomic viral variability in comparison to other HCV subtypes. Two novel regions of int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/JVI.00884-09

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Wellcome Trust More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
83
Issue:
22
Pages:
11456-11466
Publication date:
2009-11-05
Acceptance date:
2009-07-31
DOI:
ISSN:
0022-538X and 1098-5514
Pubs id:
pubs:20966
URN:
uri:370f7676-f4ab-4335-80f8-8c2903d3b37f
UUID:
370f7676-f4ab-4335-80f8-8c2903d3b37f
Local pid:
pubs:20966
Paper number:
22

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