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Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase.

Abstract:

Stearoyl-CoA desaturase-1 (SCD1) is a key enzyme in fatty acid and energy metabolism, but little is known about its nutritional regulation. Dietary methionine restriction in rats decreases hepatic Scd1 mRNA and protein, increases energy expenditure, and decreases fat-pad mass/body-weight% (FM/BW%). In humans, plasma concentrations of the methionine product, cysteine, are associated with obesity. To determine which consequences of methionine-restriction are mediated by decreased cysteine avail...

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Publication status:
Published

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Publisher copy:
10.1194/jlr.m010215

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Journal:
Journal of lipid research
Volume:
52
Issue:
1
Pages:
104-112
Publication date:
2011-01-05
DOI:
EISSN:
1539-7262
ISSN:
0022-2275
URN:
uuid:370c6209-9448-4f1a-8622-52f10448acb4
Source identifiers:
195503
Local pid:
pubs:195503

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