Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10.

Journal article

Hypertension is a significant risk factor for heart attack and stroke and represents a major public health burden because of its high prevalence (e.g. 15-20% of the European and American populations). Although blood pressure is known to have a strong genetic determination, the genes responsible for susceptibility to essential hypertension are mostly unknown. Loci involved in blood pressure regulation have been found by linkage in experimental hereditary hypertensive rat strains, but their rel...

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Authors: Julier, C; Delépine, M; Keavney, B; Terwilliger, J; Davis, S

• Publication status: Published
• Journal: Human molecular genetics
• Volume: 6
• Issue: 12
• Pages: 2077-2085
• Publication date: 1997-11-01
• DOI: 10.1093/hmg/6.12.2077
• EISSN: 1460-2083
• ISSN: 0964-6906
• Language: English
• Keywords: Blood Pressure; Hypertension; Rats; Chromosomes, Human, Pair 17; Disease Susceptibility; Sequence Homology, Nucleic Acid; Animals; Selection Bias; Genetic Linkage; Chromosome Mapping; Humans