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Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).

Abstract:

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whether antiviral function can be restored in infected individuals is unknown. To address this question, chimpanzees with persistent HCV infection were treated with anti-PD-1 antibodies. A significant reduction in HCV viremia was observed in one of thre...

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Publisher copy:
10.1073/pnas.1312772110

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
110
Issue:
37
Pages:
15001-15006
Publication date:
2013-09-29
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:36ffe9b1-2356-4e8e-be7b-d8bd2fc86c7b
Source identifiers:
426212
Local pid:
pubs:426212

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