Assessment of cumulative evidence on genetic associations: interim guidelines.

Journal article

Established guidelines for causal inference in epidemiological studies may be inappropriate for genetic associations. A consensus process was used to develop guidance criteria for assessing cumulative epidemiologic evidence in genetic associations. A proposed semi-quantitative index assigns three levels for the amount of evidence, extent of replication, and protection from bias, and also generates a composite assessment of 'strong', 'moderate' or 'weak' epidemiological credibility. In additio...

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Authors: Ioannidis, J; Boffetta, P; Little, J; O'Brien, T; Uitterlinden, A

• Publication status: Published
• Journal: International journal of epidemiology
• Volume: 37
• Issue: 1
• Pages: 120-132
• Publication date: 2008-02-01
• DOI: 10.1093/ije/dym159
• EISSN: 1464-3685
• ISSN: 0300-5771
• Language: English
• Keywords: Evidence-Based Medicine; Evaluation Studies as Topic; Female; Genetic Heterogeneity; Male; Heterozygote Detection; Epidemiologic Studies; Humans; Guidelines as Topic; Genetic Predisposition to Disease; Sensitivity and Specificity