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Transfer of 4-hydroxynonenal from parasitized to non-parasitized erythrocytes in rosettes. Proposed role in severe malaria anemia.

Abstract:

Severe anaemia is a life-threatening complication of falciparum malaria associated with loss of predominantly non-parasitized red blood cells (npRBCs). This poorly elucidated process might be influenced by (i) rosettes, i.e. npRBCs cytoadherent to haemozoin-containing parasitized RBCs (pRBCs) and (ii) generation in pRBCs of 4-hydroxynonenal (4-HNE) through haemozoin-catalysed lipid peroxidation. We explored whether close proximity in rosettes may facilitate 4-HNE transfer to npRBCs, which is ...

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Publication status:
Published

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Journal:
British journal of haematology
Volume:
157
Issue:
1
Pages:
116-124
Publication date:
2012-04-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:36f3609e-58ea-4456-a2a9-d4892adc11c8
Source identifiers:
313009
Local pid:
pubs:313009

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