Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

Journal article

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) ...

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Authors: Cortes, A; Hadler, J; Pointon, J; Robinson, P; Karaderi, T

• Publication status: Published
• Journal: Nature genetics
• Volume: 45
• Issue: 7
• Pages: 730-738
• Publication date: 2013-07-01
• DOI: 10.1038/ng.2667
• EISSN: 1546-1718
• ISSN: 1061-4036
• Language: English
• Keywords: Case-Control Studies; Spondyloarthritis Research Consortium of Canada (SPARCC); Nord-Trøndelag Health Study (HUNT); Polymorphism, Single Nucleotide; Humans; Groupe Française d'Etude Génétique des Spondylarthrites (GFEGS); Alleles; HLA-B27 Antigen; Genetic Predisposition to Disease; Genotype; Australo-Anglo-American Spondyloarthritis Consortium (TASC); DNA Mutational Analysis; Spondylitis, Ankylosing; Wellcome Trust Case Control Consortium 2 (WTCCC2); High-Throughput Nucleotide Sequencing; Risk Factors; Genetic Loci; Genotyping Techniques; Genome-Wide Association Study; Immune System Processes; International Genetics of Ankylosing Spondylitis Consortium (IGAS)