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Journal article

Halving of mortality of severe melioidosis by ceftazidime.

Abstract:

An open randomised trial was conducted to compare ceftazidime (120 mg/kg/day) with "conventional therapy" (chloramphenicol 100 mg/kg/day, doxycycline 4 mg/kg/day, trimethoprim 10 mg/kg/day, and sulphamethoxazole 50 mg/kg/day) in the treatment of severe melioidosis. A paired restricted sequential trial designed to detect a reduction in mortality from 80 to 40% in culture-positive patients surviving greater than 48 hours was stopped after 22 months. Of the 161 patients entered into the study, 6...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Chaowagul, W More by this author
Wattanagoon, Y More by this author
Wuthiekanun, V More by this author
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Journal:
Lancet
Volume:
2
Issue:
8665
Pages:
697-701
Publication date:
1989-09-05
DOI:
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:36eaca20-d7e8-446e-b39c-a85646fe485c
Source identifiers:
43177
Local pid:
pubs:43177

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