- Abstract:
-
The interaction of partially double stranded DNA oligonucleotides with HIV-1 RT was studied by investigating their ability to inhibit the homopolymeric poly(rC) directed (dG) synthesis reaction. A 20/18mer oligonucleotide, with a sequence based on the Lys3-tRNA primer region, showed stronger inhibition of the homopolymeric RT reaction than a G/C rich oligonucleotide series lacking or possessing a hairpin moiety. Interaction of the enzyme with the G/C rich oligonucleotides, as determined by IC...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.3109/14756369409020193
-
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- Journal:
- Journal of enzyme inhibition
- Volume:
- 8
- Issue:
- 2
- Pages:
- 97-112
- Publication date:
- 1994-01-05
- DOI:
- ISSN:
-
8755-5093
- URN:
-
uuid:36e16f30-a68b-4901-a857-ed224c5c38b9
- Source identifiers:
-
72675
- Local pid:
- pubs:72675
- Copyright date:
- 1994
Journal article
Inhibition of HIV-1 reverse transcriptase by defined template/primer DNA oligonucleotides: effect of template length and binding characteristics.
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