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Inhibition of HIV-1 reverse transcriptase by defined template/primer DNA oligonucleotides: effect of template length and binding characteristics.

Abstract:

The interaction of partially double stranded DNA oligonucleotides with HIV-1 RT was studied by investigating their ability to inhibit the homopolymeric poly(rC) directed (dG) synthesis reaction. A 20/18mer oligonucleotide, with a sequence based on the Lys3-tRNA primer region, showed stronger inhibition of the homopolymeric RT reaction than a G/C rich oligonucleotide series lacking or possessing a hairpin moiety. Interaction of the enzyme with the G/C rich oligonucleotides, as determined by IC...

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Publication status:
Published

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Publisher copy:
10.3109/14756369409020193

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Journal:
Journal of enzyme inhibition
Volume:
8
Issue:
2
Pages:
97-112
Publication date:
1994-01-05
DOI:
ISSN:
8755-5093
URN:
uuid:36e16f30-a68b-4901-a857-ed224c5c38b9
Source identifiers:
72675
Local pid:
pubs:72675

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