Cell cycle commitment in budding yeast emerges from the cooperation of multiple bistable switches.

Journal article

The start-transition (START) in the G1 phase marks the point in the cell cycle at which a yeast cell initiates a new round of cell division. Once made, this decision is irreversible and the cell is committed to progressing through the entire cell cycle, irrespective of arrest signals such as pheromone. How commitment emerges from the underlying molecular interaction network is poorly understood. Here, we perform a dynamical systems analysis of an established cell cycle model, which has never ...

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Authors: Zhang, T; Schmierer, B; Novák, B

• Publication status: Published
• Journal: Open biology
• Volume: 1
• Issue: 3
• Pages: 110009
• Publication date: 2011-11-01
• DOI: 10.1098/rsob.110009
• EISSN: 2046-2441
• ISSN: 2046-2441
• Language: English
• Keywords: G1 Phase; Adaptor Proteins, Signal Transducing; Mutation; Signal Transduction; Saccharomyces cerevisiae; Models, Biological; Cyclins; Saccharomyces cerevisiae Proteins; Genes, Fungal; Pheromones; Cell Cycle; Feedback, Physiological; CDC2 Protein Kinase; Cyclin-Dependent Kinase Inhibitor Proteins