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Comprehensive computational analysis of epigenetic descriptors affecting CRISPR-Cas9 off-target activity

Abstract:

Background: A common issue in CRISPR-Cas9 genome editing is off-target activity, which prevents the widespread use of CRISPR-Cas9 in medical applications. Among other factors, primary chromatin structure and epigenetics may influence off-target activity.

Methods: In this work, we utilize crisprSQL, an off-target database, to analyze the effect of 19 epigenetic descriptors on CRISPR-Cas9 off-target activity. Termed as 19 epigenetic features...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12864-022-09012-7

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Institution:
University of Oxford
Division:
MPLS
Department:
Computer Science
Role:
Author
Publisher:
BioMed Central
Journal:
BMC Genomics More from this journal
Volume:
23
Article number:
805
Publication date:
2022-12-06
Acceptance date:
2022-10-17
DOI:
EISSN:
1471-2164
Language:
English
Keywords:
Pubs id:
1311709
Local pid:
pubs:1311709
Deposit date:
2022-12-07

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