E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

Journal article

Dendritic cells (DCs) play a pivotal role in controlling the balance between tolerance and immunity in the intestine. Gut conditioned CD103(+) DCs promote regulatory T (Treg) cell responses; however, little is known about DCs that drive inflammation in the intestine. Here, we show that monocyte-derived inflammatory DCs that express E-cadherin, the receptor for CD103, promote intestinal inflammation. E-cadherin(+) DCs accumulated in the inflamed mesenteric lymph nodes and colon, had high expre...

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Authors: Siddiqui, K; Laffont, S; Powrie, F

• Publication status: Published
• Journal: Immunity
• Volume: 32
• Issue: 4
• Pages: 557-567
• Publication date: 2010-04-01
• DOI: 10.1016/j.immuni.2010.03.017
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Monocytes; Dendritic Cells; Cadherins; Cell Movement; Mice; Cell Differentiation; Gene Expression Regulation; Integrin alpha Chains; Animals; Mice, Inbred BALB C; Immunity, Innate; Antigens, CD; Antigens, CD11c; Colitis; T-Lymphocytes; Inflammation