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Does antimalarial mass drug administration increase or decrease the risk of resistance?

Abstract:

All antimalarial drugs have eventually succumbed to resistance. There is a general belief that the more people that are exposed to an antimalarial drug, the more likely it is for resistance to emerge. Mass drug administration is therefore considered a potent cause of antimalarial drug resistance. However it is the total number of parasites exposed and their individual probabilities of survival and spread that determine the risk, not the number of people that contain them. In malaria endemic a...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/S1473-3099(16)30269-9

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Department:
Oxford, MSD, NDM, Tropical Medicine
Role:
Author
Wellcome Trust More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Lancet Infectious Diseases Journal website
Volume:
17
Issue:
1
Pages:
e15–e20
Publication date:
2016-01-01
Acceptance date:
2016-05-25
DOI:
EISSN:
1474-4457
ISSN:
1473-3099
Pubs id:
pubs:636803
URN:
uri:36b0328e-48b9-4623-896a-a317700db898
UUID:
36b0328e-48b9-4623-896a-a317700db898
Local pid:
pubs:636803
Paper number:
1

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