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Systematic review of early phase pediatric clinical pharmacology trials

Abstract:

OBJECTIVE: Children have generally been excluded from early-stage clinical trials owing to safety concerns based in social expectations and not data. However, the repositioning of adult therapeutics for pediatric use and the increase in the development of therapies for pediatric only conditions require the participation of children in phase 1–2 trials. Therefore, the aim of this article is to systematically review the history and current state of early phase pediatric clin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.5863/1551-6776-27.7.609

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
ORCID:
0000-0001-8393-8536
Publisher:
Pediatric Pharmacy Advocacy Group
Journal:
Journal of Pediatric Pharmacology and Therapeutics More from this journal
Volume:
27
Issue:
7
Pages:
609-617
Place of publication:
United States
Publication date:
2022-09-26
Acceptance date:
2022-01-07
DOI:
EISSN:
2331-348X
ISSN:
1551-6776
Pmid:
36186245
Language:
English
Keywords:
Pubs id:
1285373
Local pid:
pubs:1285373
Deposit date:
2023-02-02

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