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Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children.

Abstract:

Antibodies to the highly diverse variant surface antigens (VSAs) expressed on Plasmodium falciparum-infected erythrocytes are thought to play a role in the development of naturally acquired immunity to malaria. It has been suggested that children gradually acquire immunity through the piecemeal acquisition of antibodies to a large number of VSAs over several years of exposure. However, in a cross-sectional survey of Kenyan children before the malaria-transmission season, the proportion of chi...

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Publication status:
Published

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Publisher copy:
10.1086/340420

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Volume:
185
Issue:
11
Pages:
1688-1691
Publication date:
2002-06-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:36a6ded2-290d-4e17-8b90-f7b51eda54cd
Source identifiers:
38205
Local pid:
pubs:38205

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