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Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children.

Abstract:

Antibodies to the highly diverse variant surface antigens (VSAs) expressed on Plasmodium falciparum-infected erythrocytes are thought to play a role in the development of naturally acquired immunity to malaria. It has been suggested that children gradually acquire immunity through the piecemeal acquisition of antibodies to a large number of VSAs over several years of exposure. However, in a cross-sectional survey of Kenyan children before the malaria-transmission season, the proportion of chi...

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Publication status:
Published

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Publisher copy:
10.1086/340420

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Volume:
185
Issue:
11
Pages:
1688-1691
Host title:
The Journal of infectious diseases
Publication date:
2002-06-01
Event location:
United States
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
38205

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