The equilibrium and kinetic drug binding properties of the mouse P-gp1a and P-gp1b P-glycoproteins are similar.

Journal article

The gene encoding the multidrug resistance P-glycoprotein (P-gp) is duplicated in rodent species and the functional basis for this remains unresolved. Despite a high sequence similarity, the mouse P-gp1a and P-gp1b isoforms show distinct patterns of tissue distribution which suggest a specific role of the P-gp1b isoform in steroid transport. In the present study possible biochemical differences between the isoforms were directly investigated at the level of drug interaction. There was no dete...

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Authors: Taylor, J; Ferry, DR; Higgins, C; Callaghan, R

• Journal: British journal of cancer
• Volume: 81
• Issue: 5
• Pages: 783-789
• Publication date: 1999-11-01
• DOI: 10.1038/sj.bjc.6690764
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Drug Resistance, Multiple; Cricetinae; Protein Isoforms; Nicardipine; ATP-Binding Cassette Transporters; Protein Binding; Verapamil; Progesterone; CHO Cells; P-Glycoproteins; Kinetics; Binding, Competitive; Isoquinolines; Vinblastine; Mice; Cell Membrane; Quinazolines; Animals