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Cross presentation of antigen by dendritic cells: mechanisms and implications for immunotherapy.

Abstract:

Dendritic cells (DCs) possess the specialized potential to present exogenously derived antigen to cytotoxic T lymphocytes to elicit an immune response. This process, termed cross presentation, is crucial in the generation of immune response to viruses, tumors and in autoimmune disease. The ability of DCs to cross-present exogenous antigen to cytotoxic T lymphocytes makes them an attractive target for exploitation in immunotherapy. In recent years, significant advances have been made in unders...

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Publication status:
Published

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Publisher copy:
10.1586/eci.12.45

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Expert review of clinical immunology
Volume:
8
Issue:
6
Pages:
547-555
Publication date:
2012-08-01
DOI:
EISSN:
1744-8409
ISSN:
1744-666X
Source identifiers:
352395
Language:
English
Keywords:
Pubs id:
pubs:352395
UUID:
uuid:369d0e8b-d2ce-4cd6-af32-33d85006d14f
Local pid:
pubs:352395
Deposit date:
2012-12-19

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