Successes and failures in modeling heart cell electrophysiology.

Journal article

Mathematical models of the electrical activity of the heart using equations for protein ion channels and other transporters began with the Noble 1962 model. These models then developed over a period of about 50 years. Cell types in all regions have been modeled and now are available for download from the CellML website (www.cellml.org). Simulation is a necessary tool of analysis in attempting to understand biological complexity. We often learn as much from the failures as from the successes o...

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Authors: Noble, D

• Publication status: Published
• Journal: Heart rhythm : the official journal of the Heart Rhythm Society
• Volume: 8
• Issue: 11
• Pages: 1798-1803
• Publication date: 2011-11-01
• DOI: 10.1016/j.hrthm.2011.06.014
• EISSN: 1556-3871
• ISSN: 1547-5271
• Language: English
• Keywords: Animals; Cardiac Electrophysiology; Heart; Humans; Models, Anatomic; Myocytes, Cardiac