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Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

Abstract:

A variety of models have been proposed to explain regions of recurrent somatic copy number alteration (SCNA) in human cancer. Our study employs Whole Genome DNA Sequence (WGS) data from tumor samples (n = 103) to comprehensively assess the role of the Knudson two hit genetic model in SCNA generation in prostate cancer. 64 recurrent regions of loss and gain were detected, of which 28 were novel, including regions of loss with more than 15% frequency at Chr4p15.2-p15.1 (15.53%), Chr6q27 (16.50%...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1371/journal.pgen.1007001

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Role:
Editor
Dallaglio Foundation More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS genetics Journal website
Volume:
13
Issue:
9
Pages:
e1007001
Publication date:
2017-09-25
Acceptance date:
2017-08-28
DOI:
ISSN:
1553-7404
Pubs id:
pubs:730888
URN:
uri:36802b57-60a1-4152-93a9-da4fea526c62
UUID:
uuid:36802b57-60a1-4152-93a9-da4fea526c62
Local pid:
pubs:730888

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