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The effect of remifentanil on respiratory variability, evaluated with dynamic modeling.

Abstract:

Opioid drugs disrupt signaling in the brain stem respiratory network affecting respiratory rhythm. We evaluated the influence of a steady-state infusion of a model opioid, remifentanil, on respiratory variability during spontaneous respiration in a group of 11 healthy human volunteers. We used dynamic linear and nonlinear models to examine the effects of remifentanil on both directions of the ventilatory loop, i.e., on the influence of natural variations in end-tidal carbon dioxide (Pet(CO(2)...

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Publication status:
Published

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Journal:
Journal of applied physiology (Bethesda, Md. : 1985)
Volume:
106
Issue:
4
Pages:
1038-1049
Publication date:
2009-04-05
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
URN:
uuid:36796c4e-ddb3-4c5f-a370-963078099257
Source identifiers:
243443
Local pid:
pubs:243443

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