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Development of copy number assays for detection and surveillance of piperaquine resistance associated plasmepsin 2/3 copy number variation in Plasmodium falciparum

Abstract:

Background: Long regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple locations across Southeast Asia. Genetic studies have identified single nucleotide polymorphisms as well as copy number variations in the plasmepsin 2 and plasmepsin 3 genes, which encode haem... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-020-03249-x

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Role:
Author
ORCID:
0000-0002-7131-1610
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Publisher:
Springer Nature Publisher's website
Journal:
Malaria Journal Journal website
Volume:
19
Issue:
1
Article number:
181
Publication date:
2020-05-13
Acceptance date:
2020-04-29
DOI:
EISSN:
1475-2875
Pmid:
32404110
Language:
English
Keywords:
Pubs id:
1105275
Local pid:
pubs:1105275
Deposit date:
2020-06-01

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