Journal article
Nuclear IGF1R interacts with regulatory regions of chromatin to promote RNA Polymerase II recruitment and gene expression associated with advanced tumor stage
- Abstract:
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Internalization of ligand-activated type I IGF receptor (IGF1R) is followed by recycling to the plasma membrane, degradation or nuclear translocation. Nuclear IGF1R reportedly associates with clinical response to IGF1R inhibitory drugs, yet its role in the nucleus is poorly characterized. Here, we investigated the significance of nuclear IGF1R in clinical cancers and cell line models. In prostate cancers, IGF1R was predominantly membrane localized in benign glands, while malignant epithelium ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Accepted manuscript, pdf, 2.7MB)
-
- Publisher copy:
- 10.1158/0008-5472.CAN-17-3498
Authors
Funding
Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Research Journal website
- Volume:
- 78
- Issue:
- 13
- Pages:
- 3497-3509
- Publication date:
- 2018-05-07
- Acceptance date:
- 2018-04-26
- DOI:
- EISSN:
-
1538-7445
- ISSN:
-
0008-5472
- Pmid:
-
29735545
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:847717
- UUID:
-
uuid:365abf0c-098a-4c84-b28d-267e6800d029
- Local pid:
- pubs:847717
- Source identifiers:
-
847717
- Deposit date:
- 2019-05-20
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2018
- Notes:
- © 2018 American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from the American Association for Cancer Research at: https://doi.org/10.1158/0008-5472.CAN-17-3498
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