SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

Journal article

OBJECTIVE: Single-immunoglobulin interleukin-1 receptor-related (SIGIRR), which is also known as Toll/interleukin-1 receptor 8 (TIR-8), is a member of the TIR domain-containing family of receptors and was first characterized as an inhibitor of interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) signaling. In the Dextran sulfate sodium-induced colitis model, SIGIRR(-/-) mice were shown to have increased inflammation and to be more susceptible to endotoxin challenge. Increasing evidenc...

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Authors: Drexler, S; Kong, P; Inglis, J; Williams, R; Garlanda, C

• Publication status: Published
• Journal: Arthritis and rheumatism
• Volume: 62
• Issue: 8
• Pages: 2249-2261
• Publication date: 2010-08-01
• DOI: 10.1002/art.27517
• EISSN: 1529-0131
• ISSN: 0004-3591
• Language: English
• Keywords: Signal Transduction; Inflammation; Toll-Like Receptors; Arthritis, Experimental; Humans; Mice; Mice, Knockout; Blotting, Western; Animals; Gene Transfer Techniques; RNA, Small Interfering; Dendritic Cells; Arthritis, Rheumatoid; Reverse Transcriptase Polymerase Chain Reaction; Macrophages; RNA Interference; Receptors, Interleukin-1