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A tick protein with a modified Kunitz fold inhibits human tryptase.

Abstract:

TdPI, a tick salivary gland product related to Kunitz/BPTI proteins is a potent inhibitor of human beta-tryptase. Kinetic assays suggest that three of the four catalytic sites of tryptase are blocked by TdPI, and that the inhibition of one of these involves a peptide flanking the Kunitz head. In the course of the inhibition, tryptase cleaves TdPI at several positions. Crystal structures of the TdPI head, on its own and in complex with trypsin, reveal features that are not found in classical K...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2007.03.011

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Journal:
Journal of molecular biology
Volume:
368
Issue:
4
Pages:
1172-1186
Publication date:
2007-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:364c353b-4171-4467-9374-30911cbe2dc7
Source identifiers:
30546
Local pid:
pubs:30546

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