- Abstract:
-
We recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind specifically to the surface glycoprotein (gp 120) of the R5 strain, HIV-1(Ba-L), as presented in a previous study. These aptamers potently neutralize HIV-1 infectivity in human peripheral blood mononuclear cells of both tissue culture lab-adapted strains and diverse R5 clinical isolates from multiple clades. Here, we report a detailed structural characterization of one such neutralizing aptamer, B40,...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1261/rna.7205405
-
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- Journal:
- RNA (New York, N.Y.)
- Volume:
- 11
- Issue:
- 6
- Pages:
- 873-884
- Publication date:
- 2005-06-05
- DOI:
- EISSN:
-
1469-9001
- ISSN:
-
1355-8382
- URN:
-
uuid:36435188-66ba-4e43-88a7-03456bc5b3a8
- Source identifiers:
-
16810
- Local pid:
- pubs:16810
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.
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