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Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1.

Abstract:

We recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind specifically to the surface glycoprotein (gp 120) of the R5 strain, HIV-1(Ba-L), as presented in a previous study. These aptamers potently neutralize HIV-1 infectivity in human peripheral blood mononuclear cells of both tissue culture lab-adapted strains and diverse R5 clinical isolates from multiple clades. Here, we report a detailed structural characterization of one such neutralizing aptamer, B40,...

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Publication status:
Published

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Publisher copy:
10.1261/rna.7205405

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
RNA (New York, N.Y.)
Volume:
11
Issue:
6
Pages:
873-884
Publication date:
2005-06-01
DOI:
EISSN:
1469-9001
ISSN:
1355-8382
Source identifiers:
16810
Language:
English
Keywords:
Pubs id:
pubs:16810
UUID:
uuid:36435188-66ba-4e43-88a7-03456bc5b3a8
Local pid:
pubs:16810
Deposit date:
2012-12-19

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