OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation.

Journal article

2-Oxoglutarate (2OG) and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1) is predicted to be a conserved 2OG oxygenase, the catalytic domain of which is related to hypoxia-inducible factor prolyl hydroxylases. OGFOD1 homologs in yeast are implicated in diverse cellular functions ranging from oxygen-dependent regulation of sterol response genes (Ofd1, Schizosaccharomyces pombe) to translation termination/mRNA polyadenylation (Tpa1p, Saccharomyces cerevisiae). However, neither th...

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Authors: Singleton, R; Liu-Yi, P; Formenti, F; Ge, W; Sekirnik, R

• Publication status: Published
• Publisher: National Academy of Sciences
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 111
• Issue: 11
• Pages: 4031-4036
• Publication date: 2014-03-01
• DOI: 10.1073/pnas.1314482111
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Fluorescent Antibody Technique; Hydroxylation; Yeasts; Carrier Proteins; Prolyl Hydroxylases; Ribosomal Proteins; Protein Processing, Post-Translational; Ketoglutaric Acids; Immunoblotting; Protein Biosynthesis; Humans; Proline; Nuclear Proteins; Analysis of Variance; Gene Knockdown Techniques; Computational Biology; Immunoprecipitation; Luciferases