Journal article
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.
- Abstract:
-
The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with <500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (app...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0006-3495(01)75964-4
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Bibliographic Details
- Journal:
- Biophysical journal
- Volume:
- 81
- Issue:
- 6
- Pages:
- 3308-3323
- Publication date:
- 2001-12-01
- DOI:
- EISSN:
-
1542-0086
- ISSN:
-
0006-3495
- Source identifiers:
-
9662
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:9662
- UUID:
-
uuid:363a37f7-ea6a-47df-b9e9-29774b4ce2a6
- Local pid:
- pubs:9662
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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