Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.

Barg, S; Ma, X; Eliasson, L; Galvanovskis, J; Göpel, SO; Obermüller, S; Platzer, J; Renström, E; Trus, M; Atlas, D; Striessnig, J; Rorsman, P

Abstract:

The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with <500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (app...

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APA Style

Barg, S., Ma, X., Eliasson, L., Galvanovskis, J., Göpel, S. O., Obermüller, S., Platzer, J., Renström, E., Trus, M., Atlas, D., Striessnig, J., & Rorsman, P. (2001). Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells. Biophysical Journal, 81(6), 3308–3323.

MLA Style

Barg, S., et al. “Fast Exocytosis with Few Ca(2+) Channels in Insulin-Secreting Mouse Pancreatic B Cells.” Biophysical Journal, vol. 81, no. 6, Biophysical journal, 2001, pp. 3308–23.

Chicago Style

Barg, S, X Ma, L Eliasson, J Galvanovskis, SO Göpel, S Obermüller, J Platzer, et al. 2001. “Fast Exocytosis with Few Ca(2+) Channels in Insulin-Secreting Mouse Pancreatic B Cells.” Biophysical Journal 81 (6): 3308–23.
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