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Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.

Abstract:

The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells. Nonstationary fluctuation analysis showed that the B cell is equipped with <500 alpha1(C) L-type Ca(2+) channels, corresponding to a Ca(2+) channel density of 0.9 channels per microm(2). Analysis of the kinetics of exocytosis during voltage-clamp depolarizations revealed an early component that reached a peak rate of 1.1 pFs(-1) (app...

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Publication status:
Published

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Authors


Eliasson, L More by this author
Galvanovskis, J More by this author
Göpel, SO More by this author
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Journal:
Biophysical journal
Volume:
81
Issue:
6
Pages:
3308-3323
Publication date:
2001-12-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:363a37f7-ea6a-47df-b9e9-29774b4ce2a6
Source identifiers:
9662
Local pid:
pubs:9662

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