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Molecular basis of human natural killer cell recognition of HLA-E (human leucocyte antigen-E) and its relevance to clearance of pathogen-infected and tumour cells.

Abstract:

HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule which has only limited polymorphism. It binds to the leader peptide derived from the polymorphic classical major histocompatibility molecules HLA-A, HLA-B and HLA-C. This peptide binding is highly specific and stabilizes the HLA-E protein, allowing it to migrate to the cell surface. A functioning TAP (transporter associated with antigen processing) molecule is required to transport these peptides into t...

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Publication status:
Published

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Publisher copy:
10.1042/cs19990334

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Clinical science (London, England : 1979)
Volume:
99
Issue:
1
Pages:
9-17
Publication date:
2000-07-01
Event title:
Meeting of the Medical-Research-Society
DOI:
EISSN:
1470-8736
ISSN:
0143-5221
Source identifiers:
19508

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