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Infection with a Brazilian isolate of Zika virus generates RIG‐I stimulatory RNA and the viral NS5 protein blocks type I IFN induction and signalling

Abstract:

Zika virus (ZIKV) is a major public health concern in the Americas. We report that ZIKV infection and RNA extracted from ZIKV infected cells potently activated the induction of type I interferons (IFNs). This effect was fully dependent on the mitochondrial antiviral signalling protein (MAVS), implicating RIG‐I‐like receptors (RLRs) as upstream sensors of viral RNA. Indeed, RIG‐I and the related RNA sensor MDA5 contributed to type I IFN induction in response to RNA from infected cells. We foun...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1002/eji.201847483

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM - Investigative Medicine Division
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Funding agency for:
Hertzog, J
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Funding agency for:
Rehwinkel, J
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Funding agency for:
Rehwinkel, J
Publisher:
Wiley Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
48
Issue:
7
Pages:
1120-1136
Publication date:
2018-03-23
Acceptance date:
2018-03-12
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pubs id:
pubs:831758
URN:
uri:3631e2f2-558d-4f95-9bf1-5b3d437fc615
UUID:
uuid:3631e2f2-558d-4f95-9bf1-5b3d437fc615
Local pid:
pubs:831758

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