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Association of the chaperone alphaB-crystallin with titin in heart muscle.

Abstract:

alphaB-crystallin, a major component of the vertebrate lens, is a chaperone belonging to the family of small heat shock proteins. These proteins form oligomers that bind to partially unfolded substrates and prevent denaturation. alphaB-crystallin in cardiac muscle binds to myofibrils under conditions of ischemia, and previous work has shown that the protein binds to titin in the I-band of cardiac fibers (Golenhofen, N., Arbeiter, A., Koob, R., and Drenckhahn, D. (2002) J. Mol. Cell. Cardiol. ...

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Publisher copy:
10.1074/jbc.m307473200

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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Role:
Author
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Journal:
Journal of biological chemistry
Volume:
279
Issue:
9
Pages:
7917-7924
Publication date:
2004-02-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
159815

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