The ASPP proteins complex and cooperate with p300 to modulate the transcriptional activity of p53.

Journal article

Understanding how p53 is able to specifically respond to particular stress signals and regulate many different signalling pathways remains a challenge. Several studies have demonstrated that p53's interactions with different protein partners are essential for it to be able to coordinate specific responses. In particular, the apoptotic pathway is regulated by p53 in cooperation with the Apoptosis Stimulating Proteins of p53 (ASPP) proteins. In this study, we showed that the ASPP proteins are a...

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Authors: Gillotin, S; Lu, X

• Publication status: Published
• Journal: FEBS letters
• Volume: 585
• Issue: 12
• Pages: 1778-1782
• Publication date: 2011-06-01
• DOI: 10.1016/j.febslet.2011.04.012
• EISSN: 1873-3468
• ISSN: 0014-5793
• Language: English
• Keywords: Promoter Regions, Genetic; E1A-Associated p300 Protein; Cell Line; Adaptor Proteins, Signal Transducing; Tumor Suppressor Protein p53; Humans; Apoptosis Regulatory Proteins; Transcriptional Activation