Journal article
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
- Abstract:
-
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular component...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- American Association for the Advancement of Science Publisher's website
- Journal:
- Science Journal website
- Volume:
- 365
- Issue:
- 6460
- Article number:
- eaav7188
- Publication date:
- 2019-09-27
- Acceptance date:
- 2019-08-06
- DOI:
- EISSN:
-
1095-9203
- ISSN:
-
0036-8075
- Pmid:
-
31604244
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:1061365
- UUID:
-
uuid:361dc9c3-7e9e-4c78-9f73-b1f86d665ac9
- Local pid:
- pubs:1061365
- Source identifiers:
-
1061365
- Deposit date:
- 2019-11-19
Terms of use
- Copyright holder:
- American Association for the Advancement of Science
- Copyright date:
- 2019
- Notes:
- © 2019, American Association for the Advancement of Science
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