Journal article
Combined HDAC and BET inhibition enhances melanoma vaccine immunogenicity and efficacy
- Abstract:
-
The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromodomain and extraterminal (BET) family have recently shown therapeutic efficacy against melanoma, pancreatic ductal adenocarcinoma, testicular, and lymphoma cancers in murine studies. However, in such studies, the role of the immune system in therapeutically controlling these cancers has not been explored. We sought to investigate the effect of the HDAC inhibitor romidepsin (RMD) and the BET inhibitor IBET151, ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
+ NIAID NIH HHS
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Grant:
K22 AI118421
P30 AI117943
R01 AI129797
UM1 AI126603
U19 AI096040
U19 AI128751
UM1 AI124377
Bibliographic Details
- Publisher:
- American Association of Immunologists Publisher's website
- Journal:
- Journal of Immunology Journal website
- Volume:
- 201
- Issue:
- 9
- Pages:
- 2744-2752
- Publication date:
- 2018-10-22
- Acceptance date:
- 2018-08-22
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- Pmid:
-
30249811
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:924218
- UUID:
-
uuid:3618713c-a2af-4484-881b-fdabf9f9a3db
- Local pid:
- pubs:924218
- Source identifiers:
-
924218
- Deposit date:
- 2019-03-08
Terms of use
- Copyright date:
- 2018
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