- Abstract:
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Objectives Characterization of the pharmacokinetic properties of the enantiomers of primaquine and carboxyprimaquine following administration of racemic primaquine given alone and in combination with commonly used antimalarial drugs. Methods Enantiomeric pharmacokinetics were evaluated in 49 healthy adult volunteers enrolled in three randomized cross-over studies in which a single dose of primaquine was given alone and then, after a suitable washout period, ... Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's Version
- Files:
-
-
(pdf, 2.6mb)
-
- Publisher copy:
- 10.1093/jac/dky297
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Journal of Antimicrobial Chemotherapy Journal website
- Volume:
- 73
- Issue:
- 11
- Pages:
- 3102–3113
- Publication date:
- 2018-08-03
- Acceptance date:
- 2018-06-26
- DOI:
- EISSN:
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1460-2091
- ISSN:
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0305-7453
- Pubs id:
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pubs:904982
- URN:
-
uri:36165bcd-6023-4f0e-a9b8-6b816147edff
- UUID:
-
uuid:36165bcd-6023-4f0e-a9b8-6b816147edff
- Local pid:
- pubs:904982
- Language:
- English
- Keywords:
- Copyright holder:
- Chairat et al.
- Copyright date:
- 2018
- Notes:
- © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs
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Wellcome Trust
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Bill & Melinda Gates Foundation
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Medicines for Malaria Venture
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