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Enantiospecific pharmacokinetics and drug-drug interactions of primaquine and blood-stage antimalarial drugs

Abstract:
Objectives Characterization of the pharmacokinetic properties of the enantiomers of primaquine and carboxyprimaquine following administration of racemic primaquine given alone and in combination with commonly used antimalarial drugs. Methods Enantiomeric pharmacokinetics were evaluated in 49 healthy adult volunteers enrolled in three randomized cross-over studies in which a single dose of primaquine was given alone and then, after a suitable washout period, ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/jac/dky297

Authors


Chairat, K More by this author
Jittamala, P More by this author
Hanboonkunupakarn, B More by this author
Pukrittayakamee, S More by this author
Hanpithakpong, W More by this author
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Wellcome Trust More from this funder
Bill & Melinda Gates Foundation More from this funder
Medicines for Malaria Venture More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Journal of Antimicrobial Chemotherapy Journal website
Volume:
73
Issue:
11
Pages:
3102–3113
Publication date:
2018-08-03
Acceptance date:
2018-06-26
DOI:
EISSN:
1460-2091
ISSN:
0305-7453
Pubs id:
pubs:904982
URN:
uri:36165bcd-6023-4f0e-a9b8-6b816147edff
UUID:
uuid:36165bcd-6023-4f0e-a9b8-6b816147edff
Local pid:
pubs:904982
Language:
English
Keywords:

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