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Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells

Abstract:

Inhibitors of kappa B (IκBs) -α, -β and -ε effect selective regulation of specific nuclear factor of kappa B (NF-κB) dimers according to cell lineage, differentiation state or stimulus, in a manner that is not yet precisely defined. Lymphocyte antigen receptor ligation leads to degradation of all three IκBs but activation only of subsets of NF-κB-dependent genes, including those regulated by c-Rel, such as anti-apoptotic CD40 and BAFF-R on B cells, and interleukin-2 (IL-2) in T cells. We repo...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0024504

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
6
Issue:
9
Pages:
ARTN e24504
Publication date:
2011-09-06
Acceptance date:
2011-08-12
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
227366
Language:
English
Keywords:
UUID:
uuid:36087746-d022-4e16-9007-515c9deacfb6
Local pid:
pubs:227366
Deposit date:
2013-11-16

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