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Impact of heterogeneity and effect size on the estimation of the optimal information size: analysis of recently published meta-analyses

Abstract:

Objective: To estimate the proportion of systematic reviews that meet the optimal information size (OIS) and assess the impact heterogeneity and effect size have on the OIS estimate by type of outcome (eg, mortality, semiobjective or subjective).

Methods: We carried out searches of Medline and Cochrane to retrieve meta-analyses published in systematic reviews from 2010 to 2012. We estimated the OIS using Trial Sequential Analysis software (TSA V.0.9) and based on several h...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2017-015888

Authors


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Institution:
University of Oxford
Division:
ContEd
Department:
Continuing Education
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
National Institute for Health Research More from this funder
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
7
Issue:
11
Pages:
1-9
Publication date:
2017-11-01
Acceptance date:
2017-07-14
DOI:
ISSN:
2044-6055
Source identifiers:
729913
Pubs id:
pubs:729913
UUID:
uuid:36078f40-f5e7-449e-b269-7006934aeeb0
Local pid:
pubs:729913
Deposit date:
2017-09-21

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