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Asterless licenses daughter centrioles to duplicate for the first time in Drosophila embryos.

Abstract:

Centrioles form centrosomes and cilia, and defects in any of these three organelles are associated with human disease [1]. Centrioles duplicate once per cell cycle, when a mother centriole assembles an adjacent daughter during S phase. Daughter centrioles cannot support the assembly of another daughter until they mature into mothers during the next cell cycle [2-5]. The molecular nature of this daughter-to-mother transition remains mysterious. Pioneering studies in C. elegans identified a set...

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Publication status:
Published

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Publisher copy:
10.1016/j.cub.2014.04.023

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Current biology : CB More from this journal
Volume:
24
Issue:
11
Pages:
1276-1282
Publication date:
2014-06-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Language:
English
Keywords:
Pubs id:
pubs:466019
UUID:
uuid:3606e565-933e-4763-83d3-5842e4e606db
Local pid:
pubs:466019
Source identifiers:
466019
Deposit date:
2014-06-21

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