Effects of point mutations in pVHL on the binding of HIF-1α.

Journal article

The von Hippel-Lindau tumor suppressor protein (pVHL) has an essential role in the regulation of the hypoxia response pathway in animal cells. Under normoxic conditions, the hypoxia-inducible factor (HIF) undergoes trans-4-prolyl hydroxylation and is subsequently recognised by the β-domain of pVHL, leading to the ubiquitination and degradation of HIF. Mutations of pVHL alter the binding of HIF. A subset of relevant clinically observed mutations to pVHL are thought to cause weaker binding of H...

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Authors: Domene, C; Illingworth, C

• Publication status: Published
• Journal: Proteins
• Volume: 80
• Issue: 3
• Pages: 733-746
• Publication date: 2012-03-01
• DOI: 10.1002/prot.23230
• EISSN: 1097-0134
• ISSN: 0887-3585
• Language: English
• Keywords: Protein Binding; von Hippel-Lindau Disease; Hypoxia-Inducible Factor 1, alpha Subunit; Point Mutation; Protein Stability; Molecular Dynamics Simulation; Humans; Von Hippel-Lindau Tumor Suppressor Protein; Protein Conformation