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Regulatory interactions among autologous T cell clones. Human bifunctional T cell clones regulate the activity of an autologous T cell clone.

Abstract:

In contrast to the ease of cloning and characterizing, at the molecular level, helper and cytotoxic T cells, suppressor T cells remain an enigma, and their existence as discrete entities is being increasingly challenged. Here we review evidence that CD4+ regulatory clones, capable of expressing both helper and suppressor functions, may account for much of the suppressor function. It is suggested that a single T cell clone, depending on the signals it receives from its environment, may release...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
Annals of the New York Academy of Sciences
Volume:
636
Issue:
1 Antigen and C
Pages:
135-146
Publication date:
1991-12-05
DOI:
EISSN:
1749-6632
ISSN:
0077-8923
URN:
uuid:35db938d-9e55-4fca-865e-c49e0c0662d3
Source identifiers:
482020
Local pid:
pubs:482020

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